May Health
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The REBALANCE Study is here.

REBALANCE Study is here

Recruitment for the investigational REBALANCE Study will begin in the Fall of 2023.

Women diagnosed with PCOS-related infertility and meeting the REBALANCE Study’s entry criteria may be eligible. Key entry criteria are women who:
  • Are between 18 to 40 years old.
  • Are experiencing anovulatory infertility due to PCOS.
  • Have a BMI < 40.
  • Have had no clinical response to ovulation induction treatment such as letrozole or clomiphene citrate or are contraindicated for or decline such treatment.
  • Are currently seeking immediate fertility.

Explore your eligibility for the REBALANCE study.

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Investigators at multiple centers are currently screening patients; find additional information here.

What to Expect During the Study

This one-time, in-clinic, investigational procedure, which can be done under light anesthesia, should take about an hour.
Screening
Healthcare Professional

Confirm eligibility

Day of procedure
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Transvaginal (via the vagina) ultrasound guidance is used to visualize the ovary.

A thin needle is then inserted through the vaginal wall and into the ovary, similar to the technique routinely used for egg retrieval for IVF. Radio frequency energy is then delivered to gently heat the surrounding ovarian tissue.
After procedure
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Weekly blood tests up to 3 months to check for ovulation

REBALANCE Study

Follow up calls: 24 hours, 7 days and 30 days after the procedure

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Follow up visits at the study center: 3, 6, 9, 12, 24, and 36 months after the procedure

Some participants will be part of a Control group who will receive no treatment. Participants who are randomly assigned to the Control group have the option to undergo the Ovarian Rebalancing procedure after their 3-month follow-up visit and will follow the same schedule for follow-up as described above.

The Ovarian Rebalancing procedure is currently investigational.

Get REBALANCE Study updates.

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