
The REBALANCE Study is here.

Recruitment for the REBALANCE Study will begin in the Fall of 2023.
- Are between 18 to 40 years old.
- Are experiencing anovulatory infertility due to PCOS.
- Have a BMI < 40.
- Have had no clinical response to ovulation induction treatment such as letrozole or clomiphene citrate or are contraindicated for or decline such treatment.
- Are currently seeking immediate fertility.
What to Expect During the Study

Confirm eligibility

The procedure, which should take about an hour, involves a vaginal ultrasound and use of a small catheter to apply heat to a small portion of ovarian tissue

Weekly blood tests up to 3 months to check for ovulation

Follow up calls: 24 hours, 7 days and 30 days after the procedure

Follow up visits at the study center: 3, 6, 9, 12, 24, and 36 months after the procedure
Some participants will be part of a Control group who will receive no treatment. Participants who are randomly assigned to the Control group have the option to undergo the Ovarian Rebalancing procedure after their 3-month follow-up visit and will follow the same schedule for follow-up as described above.
The Ovarian Rebalancing procedure is currently investigational, and FDA has approved the clinical trial of the procedure.