May Health
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The REBALANCE Study is here.

REBALANCE Study is here

Recruitment for the REBALANCE Study will begin in the Fall of 2023.

Women diagnosed with PCOS-related infertility and meeting the REBALANCE Study’s entry criteria may be eligible. Key entry criteria are women who:
  • Are between 18 to 40 years old.
  • Are experiencing anovulatory infertility due to PCOS.
  • Have a BMI < 40.
  • Have had no clinical response to ovulation induction treatment such as letrozole or clomiphene citrate or are contraindicated for or decline such treatment.
  • Are currently seeking immediate fertility.

What to Expect During the Study

Gaining access to the ovaries is very similar to the egg retrieval procedure that is routinely performed for in-vitro fertilization (IVF).
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Day of procedure
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The procedure, which should take about an hour, involves a vaginal ultrasound and use of a small catheter to apply heat to a small portion of ovarian tissue

After procedure
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Weekly blood tests up to 3 months to check for ovulation


Follow up calls: 24 hours, 7 days and 30 days after the procedure

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Follow up visits at the study center: 3, 6, 9, 12, 24, and 36 months after the procedure

Some participants will be part of a Control group who will receive no treatment. Participants who are randomly assigned to the Control group have the option to undergo the Ovarian Rebalancing procedure after their 3-month follow-up visit and will follow the same schedule for follow-up as described above.

The Ovarian Rebalancing procedure is currently investigational, and FDA has approved the clinical trial of the procedure.

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